One hereditary disease in humans, called xeroderma pigmentosum (XP), makes homozygous individuals exceptionally susceptible to UV-induced mutation damage in the cells of exposed tissue, especially skin. Without extraordinary avoidance of sunlight exposure, patients soon succumb to numerous skin cancers.
Which of the following best describes this phenomenon?
A) inherited cancer taking a few years to be expressedB) embryonic or fetal cancer
C) inherited predisposition to mutation
D) inherited inability to repair UV-induced mutation
E) susceptibility to chemical carcinogens
Answer: D
Given the damage caused by UV, the kind of gene affected in those with XP is one whose product is involved with
A) mending of double-strand breaks in the DNA backbone.B) breakage of cross-strand covalent bonds.
C) the ability to excise single-strand damage and replace it.
D) the removal of double-strand damaged areas.
E) causing affected skin cells to undergo apoptosis.
Answer: C
If the answers is incorrect or not given, you can answer the above question in the comment box. If the answers is incorrect or not given, you can answer the above question in the comment box.