A researcher found a method she could use to manipulate and quantify phosphorylation and methylation in embryonic cells in culture.

A researcher found a method she could use to manipulate and quantify phosphorylation and methylation in embryonic cells in culture. 



In one set of experiments using this procedure in Drosophila, she was readily successful in increasing phosphorylation of amino acids adjacent to methylated amino acids in histone tails. Which of the following results would she most likely see? 

A) increased chromatin condensation
B) decreased chromatin condensation
C) abnormalities of mouse embryos
D) decreased binding of transcription factors
E) inactivation of the selected genes


Answer: B


In one set of experiments she succeeded in decreasing methylation of histone tails. Which of the following results would she most likely see? A) increased chromatin condensation 

B) decreased chromatin condensation
C) abnormalities of mouse embryos
D) decreased binding of transcription factors
E) inactivation of the selected genes


Answer: A


One of her colleagues suggested she try increased methylation of C nucleotides in a mammalian system. Which of the following results would she most likely see? A) increased chromatin condensation 

B) decreased chromatin condensation
C) abnormalities of mouse embryos
D) decreased binding of transcription factors
E) inactivation of the selected genes



Answer: E


She tried decreasing the amount of methylation enzymes in the embryonic stem cells and then allowed the cells to further differentiate. Which of the following results would she most likely see? 

A) increased chromatin condensation
B) decreased chromatin condensation
C) abnormalities of mouse embryos
D) decreased binding of transcription factors
E) inactivation of the selected genes


Answer: C


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